NFL Week 6 Best Bets
Week 6 is a key inflection point. The market has corrected some early mistakes, but pricing can still lag behind real changes—scheme adjustments, pace shifts, offensive line issues, and defensive injuries that don’t show up cleanly in final scores. This page keeps Week 6 betting organized: schedule for planning, picks for action, and the leaderboard link for accountability.
Use it like a system. Start with the strongest positions on NFL Best Bets, compare prices and alternates on the football odds board, and track performance through the Best Bets leaderboard. Shop every number and track closing line value (CLV)—if you’re consistently beating the close, the results follow.
2025/26 NFL Week 6 Schedule
By Week 6, teams have enough film for opponents to target weaknesses—and enough reps to start countering. That creates opportunity for bettors who stay price-driven instead of headline-driven. This is also when scheduling effects start to matter more: travel, short rest, and consecutive matchup styles can impact spreads and totals even when the market is slow to adjust.
| Date | Matchup | Time | Location |
|---|---|---|---|
| Thursday, October 9, 2025 | Philadelphia @ New York | 6:15 PM | MetLife Stadium, East Rutherford, NJ |
| Sunday, October 12, 2025 | Denver @ New York | 7:30 AM | Tottenham Hotspur Stadium, London, England |
| Sunday, October 12, 2025 | Arizona @ Indianapolis | 11:00 AM | Lucas Oil Stadium, Indianapolis, IN |
| Sunday, October 12, 2025 | Los Angeles @ Miami | 11:00 AM | Hard Rock Stadium, Miami Gardens, FL |
| Sunday, October 12, 2025 | Cleveland @ Pittsburgh | 11:00 AM | Acrisure Stadium, Pittsburgh, PA |
| Sunday, October 12, 2025 | San Francisco @ Tampa Bay | 11:00 AM | Raymond James Stadium, Tampa, FL |
| Sunday, October 12, 2025 | Dallas @ Carolina | 11:00 AM | Bank of America Stadium, Charlotte, NC |
| Sunday, October 12, 2025 | Seattle @ Jacksonville | 11:00 AM | EverBank Stadium, Jacksonville, FL |
| Sunday, October 12, 2025 | Los Angeles @ Baltimore | 11:00 AM | M&T Bank Stadium, Baltimore, MD |
| Sunday, October 12, 2025 | Tennessee @ Las Vegas | 2:05 PM | Allegiant Stadium, Las Vegas, NV |
| Sunday, October 12, 2025 | Cincinnati @ Green Bay | 2:25 PM | Lambeau Field, Green Bay, WI |
| Sunday, October 12, 2025 | New England @ New Orleans | 2:25 PM | Caesars Superdome, New Orleans, LA |
| Sunday, October 12, 2025 | Detroit @ Kansas City | 6:20 PM | GEHA Field at Arrowhead Stadium, Kansas City, MO |
| Monday, October 13, 2025 | Buffalo @ Atlanta | 5:15 PM | Mercedes-Benz Stadium, Atlanta, GA |
| Monday, October 13, 2025 | Chicago @ Washington | 6:15 PM | Northwest Stadium, Landover, MD |
NFL Week 6 Picks
This section is for playable positions across spreads (ATS), totals, and moneylines—kept intentionally tight so the best edges are easy to find. Week 6 is where number quality becomes the separator. If you like a side, know the key number you need. If you like a total, shop the best price and consider how the matchup changes tempo and game script. If you’re betting moneylines, be honest about whether you’re paying too much for “the better team.”
When picks are added here, cap it at 6–10 entries and keep every pick tied to a clear cutoff. If the number moves past your playable range, the pick should be treated as a pass, not a chase. Track CLV and you’ll know if the process is working even when variance hits.
Today’s Sports Picks
Kick Off the Season with Expert Picks from AskTheBookie
AskTheBookie membership is built for bettors who want edges that translate: picks with a clear “why,” matchup notes that matter for spreads/totals/moneylines, and market movement context so you can time entries instead of reacting late. The leaderboard keeps it accountable—so you can track who’s consistently beating the market, not just popping on a heater.
To unlock full access, join or sign in here and follow picks as they post through the week. When you’re ready to finalize your Week 6 slate, return to NFL Best Bets and build your card around the best numbers available now.
