NFL Week 2 Best Bets

Week 2 is where the market starts to correct—and where bettors can get trapped by Week 1 overreactions. This page is built to keep your process tight: a full Week 2 schedule with kickoff times and locations, a dedicated picks section for spreads/totals/moneylines, and a fast path to the leaderboard so you can follow who’s producing, not who’s trending.

Use it like a checklist. Start with the strongest angles, shop numbers across books, and track closing line value (CLV) so you’re not guessing whether your entries were sharp. If you want the quick hub experience, go to NFL Best Bets for the top card, compare lines on the football odds board, and check the Best Bets leaderboard to see who’s consistently beating the number.

By content | January 5, 2026
By content | January 2, 2026

2025/26 NFL Week 2 Schedule

Week 2 betting is all about separating signal from noise. One game can swing perception, but usage trends, matchup fit, and price discipline matter more than a single final score. If a line moves fast early in the week, ask whether the number still reflects value—or if you’re paying a premium. In this window, the best approach is selective aggression: take your best spots, pass the rest, and protect CLV.

DateMatchupTimeLocation
Sunday, Sept 14, 2025Washington @ Green Bay6:15 PMLambeau Field, Green Bay, WI
Sunday, Sept 14, 2025Jacksonville @ Cincinnati11:00 AMPaycor Stadium, Cincinnati, OH
Sunday, Sept 14, 2025New York @ Dallas11:00 AMAT&T Stadium, Arlington, TX
Sunday, Sept 14, 2025Chicago @ Detroit11:00 AMFord Field, Detroit, MI
Sunday, Sept 14, 2025Los Angeles @ Tennessee11:00 AMNissan Stadium, Nashville, TN
Sunday, Sept 14, 2025New England @ Miami11:00 AMHard Rock Stadium, Miami Gardens, FL
Sunday, Sept 14, 2025San Francisco @ New Orleans11:00 AMCaesars Superdome, New Orleans, LA
Sunday, Sept 14, 2025Buffalo @ New York11:00 AMMetLife Stadium, East Rutherford, NJ
Sunday, Sept 14, 2025Seattle @ Pittsburgh11:00 AMAcrisure Stadium, Pittsburgh, PA
Sunday, Sept 14, 2025Cleveland @ Baltimore11:00 AMM&T Bank Stadium, Baltimore, MD
Sunday, Sept 14, 2025Denver @ Indianapolis2:05 PMLucas Oil Stadium, Indianapolis, IN
Sunday, Sept 14, 2025Carolina @ Arizona2:05 PMState Farm Stadium, Glendale, AZ
Sunday, Sept 14, 2025Philadelphia @ Kansas City2:25 PMGEHA Field at Arrowhead Stadium, Kansas City, MO
Sunday, Sept 14, 2025Atlanta @ Minnesota6:20 PMU.S. Bank Stadium, Minneapolis, MN
Monday, Sept 15, 2025Tampa Bay @ Houston5:00 PMNRG Stadium, Houston, TX
Monday, Sept 15, 2025Los Angeles @ Las Vegas8:00 PMAllegiant Stadium, Las Vegas, NV

NFL Week 2 Picks

This section is built for real betting decisions across spreads (ATS), totals, and moneylines. The priority is always the number: shop lines, know your cutoff, and don’t chase a play after the value is gone. Week 2 is also a prime CLV week—books adjust quickly, and small timing edges can matter as much as the matchup read.

Today’s Sports Picks

Kick Off the Season with Expert Picks from AskTheBookie

AskTheBookie membership is designed for bettors who want structure: not just picks, but the why behind spreads, totals, and moneylines—plus notes on market movement so you can time entries instead of guessing. You’ll see which angles are truly playable, where the number is doing the talking, and how to avoid forcing action just because the board is full.

To get full access, join or sign in here and follow the strongest positions as they post. For the fastest route to the top card, head to NFL Best Bets and build your Week 2 plan around your best numbers, not your busiest Sunday.