NFL Week 10 Best Bets
Week 10 is where the market is at its most confident—and where disciplined bettors can still find value by staying price-first. Teams have defined identities, books are sharper, and public opinion is louder than ever. The edge is less about discovering “who’s good” and more about getting the best number on the right spot: spreads, totals, or moneylines.
Use this page as your Week 10 control panel. Start with the strongest positions on NFL Best Bets, compare spreads/totals/moneylines on the football odds board, and stay accountable through the Best Bets leaderboard. Track closing line value (CLV) every week—if you’re not beating the close, the market is beating you.
2025/26 NFL Week 10 Schedule
By Week 10, scheduling and attrition are major handicaps. Bye weeks, short rest, travel spots, and accumulating injuries can shift pace and game scripts—especially in the second half. This is also a strong week to be selective: the board is big, but your card doesn’t need to be. Identify the matchups where the number is still wrong, shop the best price, and pass the rest.
| Date | Matchup | Time | Location |
|---|---|---|---|
| Thursday, November 6, 2025 | Las Vegas @ Denver | 7:15 PM | Empower Field at Mile High, Denver, CO |
| Sunday, November 9, 2025 | Atlanta @ Indianapolis | 8:30 AM | Olympic Stadium Berlin, Berlin, Germany |
| Sunday, November 9, 2025 | New York @ Chicago | 12:00 PM | Soldier Field, Chicago, IL |
| Sunday, November 9, 2025 | Buffalo @ Miami | 12:00 PM | Hard Rock Stadium, Miami Gardens, FL |
| Sunday, November 9, 2025 | Baltimore @ Minnesota | 12:00 PM | U.S. Bank Stadium, Minneapolis, MN |
| Sunday, November 9, 2025 | Cleveland @ New York | 12:00 PM | MetLife Stadium, East Rutherford, NJ |
| Sunday, November 9, 2025 | New England @ Tampa Bay | 12:00 PM | Raymond James Stadium, Tampa, FL |
| Sunday, November 9, 2025 | New Orleans @ Carolina | 12:00 PM | Bank of America Stadium, Charlotte, NC |
| Sunday, November 9, 2025 | Jacksonville @ Houston | 12:00 PM | NRG Stadium, Houston, TX |
| Sunday, November 9, 2025 | Arizona @ Seattle | 3:05 PM | Lumen Field, Seattle, WA |
| Sunday, November 9, 2025 | Los Angeles @ San Francisco | 3:25 PM | Levi’s Stadium, Santa Clara, CA |
| Sunday, November 9, 2025 | Detroit @ Washington | 3:25 PM | Northwest Stadium, Landover, MD |
| Sunday, November 9, 2025 | Pittsburgh @ Los Angeles | 7:20 PM | SoFi Stadium, Inglewood, CA |
| Monday, November 10, 2025 | Philadelphia @ Green Bay | 7:15 PM | Lambeau Field, Green Bay, WI |
NFL Week 10 Picks
This section is for playable positions only—spreads (ATS), totals, and moneylines—kept tight so the best edges are obvious. Week 10 is a “number quality” week: lines are efficient, and the difference between a good bet and a bad one is often a half-point, a key number, or a better price.
When picks are added here, cap it at 6–10 and tie each play to a defined range. If the spread crosses key numbers, or the total moves against you with worse juice, treat it as a different bet. Shop the line, track CLV, and don’t chase steam—passing is part of winning.
Today’s Sports Picks
Kick Off the Season with Expert Picks from AskTheBookie
AskTheBookie membership is built for bettors who want sharper execution: picks backed by matchup edges, market movement notes that help you time entries, and a disciplined approach to spreads/totals/moneylines that doesn’t rely on narrative. The leaderboard adds the accountability layer so you can track who’s consistently beating the market over the long haul.
To unlock full access, join or sign in here and follow picks as they post throughout the week. When you’re ready to build your Week 10 card around the best numbers available, return to NFL Best Bets and prioritize positions that still grade as playable at current prices.
