NFL Week 1 Best Bets
Week 1 is your clean hub for opening-week betting: a schedule you can scan fast, a picks section built for spreads, totals, and moneylines, and a quick path to the leaderboard so you know who’s earning trust with results.
Use this page to stay organized and disciplined. Start with the strongest positions on our NFL Best Bets page, compare numbers on the football odds board, and track performance on the Best Bets leaderboard. In Week 1, line shopping and closing line value (CLV) matter as much as the pick itself.
2025/26 NFL Week 1 Schedule
Week 1 betting comes with built-in volatility. Coaches are unveiling new tendencies, rookies are stepping into real snap counts, and early-season game scripts can swing harder than later weeks. That uncertainty is exactly why the market can misprice certain spots—but it’s also why you need discipline with spreads, totals, and moneylines.
Treat the schedule like a planning tool. Identify the games you’re most interested in, note the kickoff windows, and decide what you’re actually betting before the board gets noisy. If you prefer to bet early, protect CLV and be selective. If you prefer to bet late, be ready to react when limits expand and the market reveals where the sharper money is landing.
| Date | Matchup | Time (ET) | Location |
|---|---|---|---|
| Thursday, Sept 4 | Dallas Cowboys @ Philadelphia Eagles | 8:20 PM | Lincoln Financial Field, PA |
| Friday, Sept 5 | Kansas City Chiefs @ Los Angeles Chargers | 8:00 PM | Corinthians Arena, São Paulo, Brazil |
| Sunday, Sept 7 | Tampa Bay Buccaneers @ Atlanta Falcons | 1:00 PM | Mercedes-Benz Stadium, GA |
| Sunday, Sept 7 | Pittsburgh Steelers @ New York Jets | 1:00 PM | MetLife Stadium, NJ |
| Sunday, Sept 7 | Miami Dolphins @ Indianapolis Colts | 1:00 PM | Lucas Oil Stadium, IN |
| Sunday, Sept 7 | Carolina Panthers @ Jacksonville Jaguars | 1:00 PM | EverBank Stadium, FL |
| Sunday, Sept 7 | New York Giants @ Washington Commanders | 1:00 PM | FedExField, MD |
| Sunday, Sept 7 | Arizona Cardinals @ New Orleans Saints | 1:00 PM | Caesars Superdome, LA |
| Sunday, Sept 7 | Cincinnati Bengals @ Cleveland Browns | 1:00 PM | Cleveland Browns Stadium, OH |
| Sunday, Sept 7 | Las Vegas Raiders @ New England Patriots | 1:00 PM | Gillette Stadium, MA |
| Sunday, Sept 7 | San Francisco 49ers @ Seattle Seahawks | 4:05 PM | Lumen Field, WA |
| Sunday, Sept 7 | Tennessee Titans @ Denver Broncos | 4:05 PM | Empower Field at Mile High, CO |
| Sunday, Sept 7 | Detroit Lions @ Green Bay Packers | 4:25 PM | Lambeau Field, WI |
| Sunday, Sept 7 | Houston Texans @ Los Angeles Rams | 4:25 PM | SoFi Stadium, CA |
| Sunday, Sept 7 | Baltimore Ravens @ Buffalo Bills | 8:20 PM | Highmark Stadium, NY |
| Monday, Sept 8 | Minnesota Vikings @ Chicago Bears | 8:15 PM | Soldier Field, IL |
NFL Week 1 Picks
This section is built for actionable betting: spreads (ATS), totals, and moneylines with the focus on price and timing. Week 1 is not the time to get cute—if you like a side but the number is gone, pass or find a better entry. If you like a total, shop the best price and pay attention to key numbers and how the market is shaping the game script.
When you add your Week 1 picks here, keep the table tight: quality over quantity. Each play should be something you’d still bet at a clearly defined number, not a “lean” that disappears the moment the line moves. If you’re comparing two books, take the best price and track it—CLV is one of the simplest ways to audit whether your process is sharp even before results stabilize.
Today’s Sports Picks
Kick Off the Season with Expert Picks from AskTheBookie
AskTheBookie membership is built for bettors who care about process and pricing. You’re not just getting a list of plays—you’re getting the context that supports them: matchup edges, how spreads/totals/moneylines are being approached, and the market movement notes that help you time entries instead of chasing bad numbers.
You also get a clearer view of who’s hot and who’s consistent, with a leaderboard-driven approach to accountability. If you want to start Week 1 with structure, join or sign in here and focus your card around the strongest positions first. Then head back to the NFL Best Bets page to see the latest updates and finalize your entries as the market settles.
